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Anti-nNav 1.5 [4G8:1G7]


Catalogue Number 151409
Applications FACS IHC IF WB
Antigen/Gene or Protein Targets Neonatal Nav1.5 (Voltage gated Sodium Channel Nav1.5)
Reactivity Human
Relevance Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. They have also been detected in lymphocytes, glia, and fibroblasts. VGSC proteins are comprised of a core alpha-subunit, together with one or more additional regulatoy beta-subunit. VCSC expression has been detected in a number of tumour cell lines and has been implicated in the metastatic behaviour of breast and prostate cancer cells. Na(v)1.5, the major cardiac voltage-gated Na(+) channel, plays a central role in the generation of the cardiac action potential and in the propagation of electrical impulses in the heart. Its importance for normal heart function has been recently exemplified by reports of numerous mutations found in the gene SCN5A which encodes Na(v)1.5.
Host Mouse
Immunogen Peptide (14mer) from an extracellular domain of Nav1.5 - VSENIKLGNLSALR
Subclass IgM
Positive Control Cell lines over expressing Nav1.5, e.g Nav 1.5-HEK293 cells
Molecular Weight (kDa) 180-200
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain CD1
Notes 4G8:1G7 is recommended for Western blotting and Immunocytochemistry using 2ug/ml and 10ug/ml, respectively.
Research Area Cellular Transport, Neurobiology

References: 1 entry

Guo et al. 2011. Toxicol Sci. 123(1):281-9. PMID: 21693436.

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