Anti-Leu1 [Y2/178]
Invented by Dr Jacqueline Cordell from University of Oxford
Invented at University of Oxford
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151344 |
| Applications | FACS IHC IF IP WB |
| Antigen/Gene or Protein Targets | Leu1 (CD5) |
| Synonyms | CD5 Molecule 2; Lymphocyte Antigen T1/Leu-1; LEU1; CD5 Antigen; T1 |
| Reactivity | Human |
| Relevance | CD5 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukaemia cells that binds CD72. CD5 has utility for the monitoring of T-cell numbers in peripheral blood and the identification of leukaemias of T cell origin. Absence of the CD5 marker on childhood ALL cells is associated with a more favourable prognosis. |
| Host | Mouse |
| Immunogen | Normal lymphocytes treated with PHA (phytohaemagglutinin) |
| Subclass | IgG1 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| Notes | Ultroser G can be used at 1% if the cells are not growing well. |
| Research Area | Immunology, Stem Cell Biology |
References: 2 entries
Hassan et al. 2006. Mol Cell Biol. 26(17):6727-38. PMID: 16914752.
CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.
Europe PMC ID: 16914752
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References: 2 entries
Hassan et al. 2006. Mol Cell Biol. 26(17):6727-38. PMID: 16914752.
CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.
Add a reference
