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Monoclonal Antibodies

Anti-PHD1 [PHD112/G7]

Invented by Helen Turley from University of Oxford
Invented at University of Oxford
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Adapted from Andersen et al. 2011. PLoS One. 6(8):e23847. PMID: 21887331. Figure. Immunohistochemical staining. Immunohistochemical analyses of NSCLC representing high and low intensities for tumor cell expression of PHD1, PHD2, PHD3 and FIH.
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Catalogue Number 151313
Applications IHC WB
Antigen/Gene or Protein Targets Prolyl Hydroxylase 1 (PHD1)
Reactivity Human
Relevance PHD1 catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins and hydroxylates HIF-1 alpha at Pro-402 and Pro-564, and HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation.
Host Mouse
Immunogen Full length recombinant human PHD1
Positive Control MCF7 cells
Subclass IgM
Molecular Weight (kDa) 43.6
Myeloma Used P3/NS1/1-Ag4.1
Strain Balb/c
Research Area Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Metabolism

References

There are 4 reference entries for this reagent.

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References: 4 entries

Andersen et al. 2011. PLoS One. 6(8):e23847. PMID: 21887331.

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Soilleux et al. 2005. Histopathology. 47(6):602-10. PMID: 16324198.

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Stolze et al. 2004. J Biol Chem. 279(41):42719-25. PMID: 15302861.

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Appelhoff et al. 2004. J Biol Chem. 279(37):38458-65. PMID: 15247232.

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References: 4 entries

Andersen et al. 2011. PLoS One. 6(8):e23847. PMID: 21887331.

View  

Soilleux et al. 2005. Histopathology. 47(6):602-10. PMID: 16324198.

View  

Stolze et al. 2004. J Biol Chem. 279(41):42719-25. PMID: 15302861.

View  

Appelhoff et al. 2004. J Biol Chem. 279(37):38458-65. PMID: 15247232.

View  

Add a reference

Inventor Information