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Monoclonal Antibodies

Anti-p53 [Pab DO-2]

Invented by David Lane from Karolinska Institutet
Invented at University of Dundee
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Info

Catalogue Number 151292
Applications IHC IP WB
Antigen/Gene or Protein Targets p53 (N terminus)
Reactivity Human
Relevance The p53 protein is a stress-regulated transcription factor that regulates cell cycle arrest and was first identified as an SV40 large T antigen-binding protein. Mutation of p53 is the most common genetic change so far identified in a number of major carcinomas.
Host Mouse
Positive Control MDA-MB-231 cell line
Subclass IgG1
Molecular Weight (kDa) 53
Recommended Growing Conditions DMEM + 5% FCS
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

References

There are 8 reference entries for this reagent.

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References: 8 entries

Sonnemann et al. 2011. Eur J Cancer. 47(9):1432-41. PMID: 21334198.

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Anticancer effects of the p53 activator nutlin-3 in Ewing's sarcoma cells.

Europe PMC ID: 21334198

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Zaman et al. 2007. Cancer Res. 67(20):10078-86. PMID: 17942942.

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Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice.

Europe PMC ID: 17942942

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Stephen et al. 1995. J Mol Biol. 248(1):58-78. PMID: 7537340.

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Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions.

Europe PMC ID: 7537340

View  

Vojtĕsek et al. 1992. J Immunol Methods. 151(1-2):237-44. PMID: 1378473.

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An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53.

Europe PMC ID: 1378473

View  

Add a reference

References: 8 entries

Sonnemann et al. 2011. Eur J Cancer. 47(9):1432-41. PMID: 21334198.

View  

Anticancer effects of the p53 activator nutlin-3 in Ewing's sarcoma cells.

View  

Zaman et al. 2007. Cancer Res. 67(20):10078-86. PMID: 17942942.

View  

Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice.

View  

Stephen et al. 1995. J Mol Biol. 248(1):58-78. PMID: 7537340.

View  

Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions.

View  

Vojtĕsek et al. 1992. J Immunol Methods. 151(1-2):237-44. PMID: 1378473.

View  

An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53.

View  

Add a reference

Inventor Information