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|Applications||IHC IP WB|
|Antigen/Gene or Protein Targets||p53 (N terminus)|
|Relevance||The p53 protein is a stress-regulated transcription factor that regulates cell cycle arrest and was first identified as an SV40 large T antigen-binding protein. Mutation of p53 is the most common genetic change so far identified in a number of major carcinomas.|
|Positive Control||MDA-MB-231 cell line|
|Molecular Weight (kDa)||53|
|Recommended Growing Conditions||DMEM + 5% FCS|
|Research Area||Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling|
References: 4 entries
Sonnemann et al. 2011. Eur J Cancer. 47(9):1432-41. PMID: 21334198.
Zaman et al. 2007. Cancer Res. 67(20):10078-86. PMID: 17942942.
Stephen et al. 1995. J Mol Biol. 248(1):58-78. PMID: 7537340.
Vojtĕsek et al. 1992. J Immunol Methods. 151(1-2):237-44. PMID: 1378473.
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