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Anti-p53 [Pab DO-2]


Catalogue Number 151292
Applications IHC IP WB
Antigen/Gene or Protein Targets p53 (N terminus)
Reactivity Human
Relevance The p53 protein is a stress-regulated transcription factor that regulates cell cycle arrest and was first identified as an SV40 large T antigen-binding protein. Mutation of p53 is the most common genetic change so far identified in a number of major carcinomas.
Host Mouse
Subclass IgG1
Positive Control MDA-MB-231 cell line
Molecular Weight (kDa) 53
Recommended Growing Conditions DMEM + 5% FCS
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 4 entries

Sonnemann et al. 2011. Eur J Cancer. 47(9):1432-41. PMID: 21334198.

Zaman et al. 2007. Cancer Res. 67(20):10078-86. PMID: 17942942.

Stephen et al. 1995. J Mol Biol. 248(1):58-78. PMID: 7537340.

Vojtĕsek et al. 1992. J Immunol Methods. 151(1-2):237-44. PMID: 1378473.

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