Anti-HIF2A [Hif2a 237]
Invented by Helen Turley from University of Oxford
Invented at University of Oxford
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Info
| Catalogue Number | 151262 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Hypoxia-inducible factor 2, alpha subunit (HIF2A) |
| Reactivity | Human |
| Relevance | Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF2A is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF1A has been observed in varying subsets of tumour cells from various solid tumours. HIF2A is also a potent activator of the tie2 gene, which is known to be selectively expressed in endothelial cells. |
| Host | Mouse |
| Subclass | IgG2b |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Strain | Balb/c |
| Research Area | Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Metabolism |
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