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Monoclonal Antibodies

Anti-XRCC3 [XRCC3 10F1/6]

Invented by Dr Stephen West from Francis Crick Institute
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
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Purified RAD51C–XRCC3 complex. Proteins were purified from Sf9 cells infected with pBAC51Chis10 and pBACX3his6 and visualized by SDS-PAGE followed by Coomassie blue staining. (Lane a) Molecular mass markers; (lane b) 3 μg of RAD51C–XRCC3 complex. Adapted from Fig 5, Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635
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Image thumbnail for Anti-XRCC3 [XRCC3 10F1/6]
Catalogue Number 151256
Applications IHC WB
Antigen/Gene or Protein Targets XRCC3
Reactivity Human
Relevance X-Ray Repair Cross Complementing 3 (XRCC3) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC3 is also a component of the homologous recombination pathway.
Host Mouse
Immunogen His-tagged human XRCC3
Positive Control HeLa nuclear extracts.
Subclass IgG1
Molecular Weight (kDa) 37.8
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Bacteriology, DNA Damage and Repair, Epigenetics & Nuclear Signalling

References

There are 5 reference entries for this reagent.

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References: 5 entries

Agostini et al. 2015. Cancer Biol Ther. 16(8):1160-71. PMID: 26023803.

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Li et al. 2014. Sci Signal. 7(326):ra47. PMID: 24847116.

IHC

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Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635.

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Masson et al. 2001. Proc Natl Acad Sci U S A. 98(15):8440-6. PMID: 11459987.

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Tebbs et al. 1995. Proc Natl Acad Sci U S A. 92(14):6354-8. PMID: 7603995.

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References: 5 entries

Agostini et al. 2015. Cancer Biol Ther. 16(8):1160-71. PMID: 26023803.

View  

Li et al. 2014. Sci Signal. 7(326):ra47. PMID: 24847116.

IHC

View  

Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635.

View  

Masson et al. 2001. Proc Natl Acad Sci U S A. 98(15):8440-6. PMID: 11459987.

View  

Tebbs et al. 1995. Proc Natl Acad Sci U S A. 92(14):6354-8. PMID: 7603995.

View  

Add a reference

Inventor Information