Cat. #151256
Anti-XRCC3 [XRCC3 10F1/6] mAb
Cat. #: 151256
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: XRCC3
Class: Monoclonal
Application: IHC ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Stephen West
Institute: Cancer Research UK, London Research Institute: Clare Hall Laboratories
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-XRCC3 [XRCC3 10F1/6] mAb
- Clone: XRCC3 10F1/6
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 37.8 kDa
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: IHC ; WB
- Description: X-Ray Repair Cross Complementing 3 (XRCC3) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC3 is also a component of the homologous recombination pathway.
- Immunogen: His-tagged human XRCC3
- Isotype: IgG1
- Myeloma used: Sp2/0-Ag14
- Recommended controls: HeLa nuclear extracts.
Target Details
- Target: XRCC3
- Molecular weight: 37.8 kDa
- Tissue cell line specificity: HeLa nuclear extracts.
- Target background: X-Ray Repair Cross Complementing 3 (XRCC3) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC3 is also a component of the homologous recombination pathway.
Applications
- Application: IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.94 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Agostini et al. 2015. Cancer Biol Ther. 16(8):1160-71. PMID: 26023803.
- Li et al. 2014. Sci Signal. 7(326):ra47. PMID: 24847116.
- Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635.
- Identification and purification of two distinct complexes containing the five RAD51 paralogs.
- Masson et al. 2001. Proc Natl Acad Sci U S A. 98(15):8440-6. PMID: 11459987.
- Complex formation by the human RAD51C and XRCC3 recombination repair proteins.
- Tebbs et al. 1995. Proc Natl Acad Sci U S A. 92(14):6354-8. PMID: 7603995.
- Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.
