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Anti-Integrin b1 [4B7]


Catalogue Number 151222
Applications FACS IHC IF IP Fn
Antigen/Gene or Protein Targets Integrin ß1 (CD29)
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Loss of integrin beta 1 is associated with the development of some epithelial tumours.
Host Mouse
Immunogen Ocular melanoma cell line V+B2
Subclass IgG1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Frozen Sections (2 µg/ml)
Immunofluorescence (2.5 µg/ml)
Immunoprecipitation (1 µg/sample)
Paraffin Sections (2 µg/ml, no pre-treatment required)
Immunoblotting (not recommended)
Research Area Adhesion, Developmental Biology, Drug Discovery & Development, Stem Cell Biology

References: 1 entry

Marshall et al. 1998. Br J Cancer. 77(4):522-9. PMID: 9484806.

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