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Anti-Integrin a4 [7.2]


Catalogue Number 151218
Applications FACS IHC IP WB
Antigen/Gene or Protein Targets Integrin alpha 4 (VLA-4; CD49d)
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 4 Combines with beta-1 integrin to form the Integrin alpha4/beta1 lymphocyte homing receptor: Very Late Antigen 4 (VLA-4). VLA-4 plays a major role in lymphocyte extravasation, via binding to VCAM on endothelial cells. VLA-4 also binds fibronectin and mediates homotypic and heterotypic cell-cell adhesion between lymphocytes.
Host Mouse
Immunogen Human melanoma line DX3
Subclass IgG1
Positive Control U937 human histiocytic lymphoma cell line
Notes Recommended for Histology on unfixed tissue culture cells.
Research Area Adhesion, Cardiovascular, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References: 2 entries

McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.

Leitinger et al. 2002. J Cell Sci. 115(Pt 5):963-72. PMID: 11870215.

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