Anti-Integrin a4 [7.2]
Invented at Queen Mary University of London
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151218 |
| Applications | FACS IHC IP WB |
| Antigen/Gene or Protein Targets | Integrin alpha 4 (VLA-4; CD49d) |
| Reactivity | Human |
| Relevance |
Monoclonal antibody directed at integrin a4/b1, which forms part of VLA-4. Background and Research Application Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 4 combines with beta-1 integrin to form the Integrin alpha4/ beta1 lymphocyte homing receptor: Very Late Antigen 4 (VLA-4). VLA-4 plays a major role in lymphocyte extravasation, via binding to VCAM on endothelial cells. VLA-4 also binds fibronectin and mediates homotypic and heterotypic cell-cell adhesion between lymphocytes. Integrin alpha 4/ beta 1 also binds the mucosal addressin cell adhesion molecule (MAdCAM-1). |
| Host | Mouse |
| Immunogen | Human melanoma line DX3 |
| Immunogen UniProt ID | P13612 |
| Positive Control | U937 human histiocytic lymphoma cell line |
| Subclass | IgG1 |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest Recommended for histology on unfixed tissue culture cells. Concentration 1mg/ml as standard |
| Research Area | Adhesion, Cardiovascular, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology |
References: 4 entries
McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
Europe PMC ID: 12511588
Leitinger et al. 2002. J Cell Sci. 115(Pt 5):963-72. PMID: 11870215.
The involvement of lipid rafts in the regulation of integrin function.
Europe PMC ID: 11870215
Add a reference
References: 4 entries
McDowall et al. 2003. J Clin Invest. 111(1):51-60. PMID: 12511588.
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
Leitinger et al. 2002. J Cell Sci. 115(Pt 5):963-72. PMID: 11870215.
The involvement of lipid rafts in the regulation of integrin function.
Add a reference
