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Anti-Leu2 [UCH-T4]

Invented by Prof Peter Beverley at Imperial College

Info

Catalogue Number 151177
Applications FACS IHC IF
Antigen/Gene or Protein Targets Leu2 (CD8)
Reactivity Human
Relevance Leu-2 is a T cell co-receptor that recognises, together with the T cell receptor, MHC class I molecules. Leu-2 is present on human suppressor / cytotoxic T cells, 30% of circulating T cells. UCH-T4 is recommended for: the detection of immunoregulatory T cell subset imbalances in autoimmune disorders and immunodeficiency states, categorisation of T cell acute lymphoblastic leukaemia and lymphoblastic lymphoma in conjunction with other antigens and determination of T4/T8 ratios in immune deficiencies, rheumatoid arthritis, multiple sclerosis, etc.
Host Mouse
Immunogen Thymocytes followed by Sezary T cells.
Subclass IgG2a
Molecular Weight (kDa) 32
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Immunology, Stem Cell Biology

References: 7 entries

Beverley P. 1982. Proc. Royal Soc. Edin. 81B:221-232

Waleh et al. 2011. Pediatr Res. 70(4):332-8. PMID: 21691249.

Anatomic closure of the premature patent ductus arteriosus: The role of CD14+/CD163+ mononuclear cells and VEGF in neointimal mound formation.

Europe PMC ID: 21691249

Martín et al. 2002. J Cutan Pathol. 29(6):347-53. PMID: 12135465.

Vascular endothelium express CS-1 fibronectin in allergic contact dermatitis.

Europe PMC ID: 12135465

Kee et al. 2000. J Cell Biochem. 78(1):97-111. PMID: 10797569.

beta1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum.

Europe PMC ID: 10797569


Add a reference

References: 7 entries

Beverley P. 1982. Proc. Royal Soc. Edin. 81B:221-232

Waleh et al. 2011. Pediatr Res. 70(4):332-8. PMID: 21691249.

Anatomic closure of the premature patent ductus arteriosus: The role of CD14+/CD163+ mononuclear cells and VEGF in neointimal mound formation.

Europe PMC ID: 21691249

Martín et al. 2002. J Cutan Pathol. 29(6):347-53. PMID: 12135465.

Vascular endothelium express CS-1 fibronectin in allergic contact dermatitis.

Europe PMC ID: 12135465

Kee et al. 2000. J Cell Biochem. 78(1):97-111. PMID: 10797569.

beta1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum.

Europe PMC ID: 10797569


Add a reference

References: 7 entries

Beverley P. 1982. Proc. Royal Soc. Edin. 81B:221-232

Waleh et al. 2011. Pediatr Res. 70(4):332-8. PMID: 21691249.

Anatomic closure of the premature patent ductus arteriosus: The role of CD14+/CD163+ mononuclear cells and VEGF in neointimal mound formation.

Martín et al. 2002. J Cutan Pathol. 29(6):347-53. PMID: 12135465.

Vascular endothelium express CS-1 fibronectin in allergic contact dermatitis.

Kee et al. 2000. J Cell Biochem. 78(1):97-111. PMID: 10797569.

beta1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum.


Add a reference


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