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|Applications||FACS IHC IP|
|Antigen/Gene or Protein Targets||Integrin alpha6 (CD49f)|
|Relevance||Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 6 is found on epithelial and endothelial basement membranes and colorectal carcinoma. Integrin alpha 6 associates with integrin beta 4 to form integrin a6b4, one of the most abundant keratinocyte integrins, and binds laminin. MP 4F10 may be used in clinical studies for tumour grading as it will stain both moderately and well-differentiated colorectal adenocarcinoma.|
|Immunogen||SW1222 human colorectal cell line.|
|Recommended Growing Conditions||DMEM + 5% FCS|
|Research Area||Adhesion, Developmental Biology, Stem Cell Biology|
References: 4 entries
Svensson Månsson et al. 2007. J Pathol. 212(1):102-11. PMID: 17370299.
Levy et al. 2000. Mol Biol Cell. 11(2):453-66. PMID: 10679006.
Anbazhagan et al. 1995. J Pathol. 176(3):227-32. PMID: 7674085.
Pignatelli et al. 1990. Proc Natl Acad Sci U S A. 87(4):1541-5. PMID: 2304917.
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