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Anti-Integrin a6 [MP4F10]


Catalogue Number 151134
Applications FACS IHC IP
Antigen/Gene or Protein Targets Integrin alpha6 (CD49f)
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 6 is found on epithelial and endothelial basement membranes and colorectal carcinoma. Integrin alpha 6 associates with integrin beta 4 to form integrin a6b4, one of the most abundant keratinocyte integrins, and binds laminin. MP 4F10 may be used in clinical studies for tumour grading as it will stain both moderately and well-differentiated colorectal adenocarcinoma.
Host Mouse
Immunogen SW1222 human colorectal cell line.
Subclass IgG2b
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Adhesion, Developmental Biology, Stem Cell Biology

References: 4 entries

Svensson Månsson et al. 2007. J Pathol. 212(1):102-11. PMID: 17370299.

Levy et al. 2000. Mol Biol Cell. 11(2):453-66. PMID: 10679006.

Anbazhagan et al. 1995. J Pathol. 176(3):227-32. PMID: 7674085.

Pignatelli et al. 1990. Proc Natl Acad Sci U S A. 87(4):1541-5. PMID: 2304917.

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