Cat. #151134
Anti-Integrin alpha 6 [MP4F10]
Cat. #: 151134
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-5 days
Target: Integrin alpha6 (CD49f)
Class: Monoclonal
Application: IF ; ICC ; FACS ; IHC ; IP ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Walter Bodmer
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-Integrin alpha 6 [MP4F10]
- Clone: MP4F10
- Tool type ecom: Antibodies
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 118/100
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: IF ; ICC ; FACS ; IHC ; IP ; WB
- Description: MP 4F10 may be used in clinical studies for tumour grading as it will stain both moderately and well-differentiated colorectal adenocarcinoma.
- Immunogen: SW1222 human colorectal cell line.
- Isotype: IgG1 kappa
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Integrin alpha6 (CD49f)
- Molecular weight: 118/100
- Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha 6 is found on epithelial and endothelial basement membranes and colorectal carcinoma. Integrin alpha 6 associates with integrin beta 4 to form integrin a6b4, one of the most abundant keratinocyte integrins, and binds laminin.
Applications
- Application: IF ; ICC ; FACS ; IHC ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Zhou et al. 2019. Stem Cell Res Ther. 10(1):155. PMID: 31151466.
- Pieri et al. 2019. Stem Cell Res Ther. 10(1):135. PMID: 31109365.
- Kapsokalyvas et al. 2017. Colloids Surf B Biointerfaces. 159:97-107. PMID: 28780465.
- Zhang et al. 2017. PLoS One. 12(2):e0172207. PMID: 28234938.
- Zhang et al. 2016. Cell Reprogram. 18(6):401-410. PMID: 27906584.
- Al Thawadi et al. 2016. Oncotarget. 7(5):5289-305. PMID: 26700621.
- Stempin et al. 2015. Cancer Cell Int. 15:110. PMID: 26612978.
- Svensson M
nsson et al. 2007. J Pathol. 212(1):102-11. PMID: 17370299. - Transcriptional upregulation and unmethylation of the promoter region of p16 in invasive basal cell carcinoma cells and partial co-localization with the gamma 2 chain of laminin-332.
- Levy et al. 2000. Mol Biol Cell. 11(2):453-66. PMID: 10679006.
- beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms.
- Anbazhagan et al. 1995. J Pathol. 176(3):227-32. PMID: 7674085.
- Expression of integrin subunits in the human infant breast correlates with morphogenesis and differentiation.
- Pignatelli et al. 1990. Proc Natl Acad Sci U S A. 87(4):1541-5. PMID: 2304917.
- Carcinoembryonic antigen functions as an accessory adhesion molecule mediating colon epithelial cell-collagen interactions.
