- Reviews (0)
|Applications||FACS IHC IF IP Fn|
|Antigen/Gene or Protein Targets||Integrin alpha 2b (CD41)|
|Synonyms||Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR|
|Relevance||Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha 2b (CD41) and integrin ß3 (CD61) associate to form the heterodimer integrin a2bß3 (CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed in platelets. M148 prevents aggregation of platelets. Used for imaging and therapy of thrombi. M148 binds to some medulloblastoma and neuroblastoma cells and rhabdomyosarcoma and certain other solid tumours. No binding is observed to marrow constituents other than platelets and megakaryocytes. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.|
|Immunogen||Homogenized human medulloblastoma tissue.|
|Positive Control||human platelets and megakaryocytes|
|Molecular Weight (kDa)||110-130|
|Recommended Growing Conditions||DMEM + 5% FCS|
|Notes||M148 inhibits ADP-induced fibrinogen binding and platelet aggregation (Jones et al., 1984)|
References: 4 entries
Alonso-Orgaz et al. 2014. J Proteomics. 109:368-81. PMID: 25065646.
Cloutier et al. 2013. EMBO Mol Med. 5(2):235-49. PMID: 23165896.
Boilard et al. 2011. J Immunol. 186(7):4361-6. PMID: 21357261.
Jones et al. 1984. Br J Haematol. 57(4):621-31. PMID: 6234927.
Add a reference
Have you used this reagent? Share your experience by submitting a review and help your fellow scientists.Review this reagent