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Anti-Integrin a2b [M148]

Invented by Dr JOHN KEMSHEAD at SHIRE PHARMACEUTICALS

Info

Catalogue Number 151128
Applications FACS IHC IF IP Fn
Antigen/Gene or Protein Targets Integrin alpha 2b (CD41)
Synonyms Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha 2b (CD41) and integrin ß3 (CD61) associate to form the heterodimer integrin a2bß3 (CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed in platelets. M148 prevents aggregation of platelets. Used for imaging and therapy of thrombi. M148 binds to some medulloblastoma and neuroblastoma cells and rhabdomyosarcoma and certain other solid tumours. No binding is observed to marrow constituents other than platelets and megakaryocytes. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.
Host Mouse
Immunogen Homogenized human medulloblastoma tissue.
Subclass IgG1
Positive Control human platelets and megakaryocytes
Molecular Weight (kDa) 110-130
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes M148 inhibits ADP-induced fibrinogen binding and platelet aggregation (Jones et al., 1984)
Research Area Cancer

References: 8 entries

Alonso-Orgaz et al. 2014. J Proteomics. 109:368-81. PMID: 25065646.

IHC

Proteomic characterization of human coronary thrombus in patients with ST-segment elevation acute myocardial infarction.

Europe PMC ID: 25065646

Cloutier et al. 2013. EMBO Mol Med. 5(2):235-49. PMID: 23165896.

The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes.

Europe PMC ID: 23165896

Boilard et al. 2011. J Immunol. 186(7):4361-6. PMID: 21357261.

Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generation.

Europe PMC ID: 21357261

Jones et al. 1984. Br J Haematol. 57(4):621-31. PMID: 6234927.

IF Fn

A monoclonal antibody binding to human medulloblastoma cells and to the platelet glycoprotein IIB-IIIA complex.

Europe PMC ID: 6234927


Add a reference

References: 8 entries

Alonso-Orgaz et al. 2014. J Proteomics. 109:368-81. PMID: 25065646.

IHC

Proteomic characterization of human coronary thrombus in patients with ST-segment elevation acute myocardial infarction.

Europe PMC ID: 25065646

Cloutier et al. 2013. EMBO Mol Med. 5(2):235-49. PMID: 23165896.

The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes.

Europe PMC ID: 23165896

Boilard et al. 2011. J Immunol. 186(7):4361-6. PMID: 21357261.

Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generation.

Europe PMC ID: 21357261

Jones et al. 1984. Br J Haematol. 57(4):621-31. PMID: 6234927.

IF Fn

A monoclonal antibody binding to human medulloblastoma cells and to the platelet glycoprotein IIB-IIIA complex.

Europe PMC ID: 6234927


Add a reference

References: 8 entries

Alonso-Orgaz et al. 2014. J Proteomics. 109:368-81. PMID: 25065646.

IHC

Proteomic characterization of human coronary thrombus in patients with ST-segment elevation acute myocardial infarction.

Cloutier et al. 2013. EMBO Mol Med. 5(2):235-49. PMID: 23165896.

The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes.

Boilard et al. 2011. J Immunol. 186(7):4361-6. PMID: 21357261.

Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generation.

Jones et al. 1984. Br J Haematol. 57(4):621-31. PMID: 6234927.

IF Fn

A monoclonal antibody binding to human medulloblastoma cells and to the platelet glycoprotein IIB-IIIA complex.


Add a reference


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