Anti-Integrin a2b [M148] mAb

Tool Details

*FOR RESEARCH USE ONLY

• Name: Anti-Integrin a2b [M148] mAb
• Alternate name: Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR
• Clone: M148
• Tool sub type: Primary antibody
• Class: Monoclonal
• Purpose: Marker
• Conjugation: Unconjugated
• Molecular weight: 110-130 kDa
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: FACS ; IHC ; IF ; IP ; Fn
• Description: M148 prevents aggregation of platelets. Used for imaging and therapy of thrombi. M148 binds to some medulloblastoma and neuroblastoma cells and rhabdomyosarcoma and certain other solid tumours. No binding is observed to marrow constituents other than platelets and megakaryocytes.
• Immunogen: Homogenized human medulloblastoma tissue.
• Isotype: IgG1
• Myeloma used: P3X63Ag8.653
• Recommended controls: human platelets and megakaryocytes

Target Details

• Target: Integrin alpha 2b (CD41)
• Molecular weight: 110-130 kDa
• Tissue cell line specificity: human platelets and megakaryocytes
• Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Integrin alpha 2b (CD41) and integrin ?3 (CD61) associate to form the heterodimer integrin a2b?3 (CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed in platelets. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic c...

Applications

• Application: FACS ; IHC ; IF ; IP ; Fn

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Alonso-Orgaz et al. 2014. J Proteomics. 109:368-81. PMID: 25065646.
• Proteomic characterization of human coronary thrombus in patients with ST-segment elevation acute myocardial infarction.
• Cloutier et al. 2013. EMBO Mol Med. 5(2):235-49. PMID: 23165896.
• The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes.
• Boilard et al. 2011. J Immunol. 186(7):4361-6. PMID: 21357261.
• Platelets partici...