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Anti-Keratin14 [LL001]

Info

Catalogue Number 151121
Applications IHC IF IP WB
Antigen/Gene or Protein Targets Keratin 14
Reactivity Human, Mouse and Pig
Relevance Keratin 14, a type 1 intermediate filament protein, is one of the two keratins which distinguish stratifying epithelial cell types from simple epithelial cell types. This protein can be detected in intermediate filaments and stratified squamous epithelial cells; in the basal (myoepithelial) cells of glandular epithelia and all cells of keratinocyte lineage, including tumours. LL001 therefore characterises stratifying/keratinocyte cell types.
Host Mouse
Immunogen Peptide (last 16 carboxy-terminal amino acids of human keratin) coupled to thyroglobulin by the extra Cys added at the N terminus.
Subclass IgG2a kappa
Molecular Weight (kDa) 50
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes LL001 may be used on formalin fixed sections but is more effective on unfixed frozen sections.
Research Area Cell Signaling & Signal Transduction

References: 10 entries

Sun et al. 2011. Endocrinology. 152(8):3233-45. PMID: 21628386.

Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2.

Europe PMC ID: 21628386

Karashima et al. 2002. J Cell Sci. 115(Pt 24):5027-37. PMID: 12432088.

Interaction of periplakin and envoplakin with intermediate filaments.

Europe PMC ID: 12432088

D'Alessandro et al. 2002. J Cell Sci. 115(Pt 22):4341-51. PMID: 12376565.

Keratin mutations of epidermolysis bullosa simplex alter the kinetics of stress response to osmotic shock.

Europe PMC ID: 12376565

Purkis et al. 1990. J Cell Sci. 97 ( Pt 1):39-50. PMID: 1701769.

Antibody markers of basal cells in complex epithelia.

Europe PMC ID: 1701769

Leigh et al. 1988. J Invest Dermatol. 90(5):639-42. PMID: 3283248.

Type VII collagen is a normal component of epidermal basement membrane, which shows altered expression in recessive dystrophic epidermolysis bullosa.

Europe PMC ID: 3283248


Add a reference

References: 10 entries

Sun et al. 2011. Endocrinology. 152(8):3233-45. PMID: 21628386.

Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2.

Europe PMC ID: 21628386

Karashima et al. 2002. J Cell Sci. 115(Pt 24):5027-37. PMID: 12432088.

Interaction of periplakin and envoplakin with intermediate filaments.

Europe PMC ID: 12432088

D'Alessandro et al. 2002. J Cell Sci. 115(Pt 22):4341-51. PMID: 12376565.

Keratin mutations of epidermolysis bullosa simplex alter the kinetics of stress response to osmotic shock.

Europe PMC ID: 12376565

Purkis et al. 1990. J Cell Sci. 97 ( Pt 1):39-50. PMID: 1701769.

Antibody markers of basal cells in complex epithelia.

Europe PMC ID: 1701769

Leigh et al. 1988. J Invest Dermatol. 90(5):639-42. PMID: 3283248.

Type VII collagen is a normal component of epidermal basement membrane, which shows altered expression in recessive dystrophic epidermolysis bullosa.

Europe PMC ID: 3283248


Add a reference

References: 10 entries

Sun et al. 2011. Endocrinology. 152(8):3233-45. PMID: 21628386.

Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2.

Karashima et al. 2002. J Cell Sci. 115(Pt 24):5027-37. PMID: 12432088.

Interaction of periplakin and envoplakin with intermediate filaments.

D'Alessandro et al. 2002. J Cell Sci. 115(Pt 22):4341-51. PMID: 12376565.

Keratin mutations of epidermolysis bullosa simplex alter the kinetics of stress response to osmotic shock.

Purkis et al. 1990. J Cell Sci. 97 ( Pt 1):39-50. PMID: 1701769.

Antibody markers of basal cells in complex epithelia.

Leigh et al. 1988. J Invest Dermatol. 90(5):639-42. PMID: 3283248.

Type VII collagen is a normal component of epidermal basement membrane, which shows altered expression in recessive dystrophic epidermolysis bullosa.


Add a reference


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