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Anti-NCAM [ERIC-1]

Invented by Dr JOHN KEMSHEAD at SHIRE PHARMACEUTICALS

Info

Catalogue Number 151092
Applications ELISA FACS IHC IF IP RIA WB
Antigen/Gene or Protein Targets Neural Cell Adhesion Molecule (NCAM; CD56)
Synonyms Neural Cell Adhesion Molecule; NCAM; CD56 Antigen; MSK39
Reactivity Human
Relevance NCAM, also known as CD56, is a homophillic binding glycoprotein present on a variety of neural cells including neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synatptic plasticity, learning and memory and in the development of the nervous system.
Host Mouse
Immunogen Retinoblastoma tissue membrane fraction
Subclass IgG1
Positive Control Neuroblastome
Molecular Weight (kDa) 180, 140, 120
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes In the mouse brain, 3 main isoforms have been described of 180,140 and 120 kDa MW. A Western blot of 2 year old pediatric brain revealed bands of 180,140 and 120 kDa (weakly) with ERIC-1.
Research Area Adhesion, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Neurobiology, Stem Cell Biology

References: 18 entries

Marković-Lipkovski et al. 2015. PLoS One. 10(9):e0137028. PMID: 26327314.

IHC IF

Variable Expression of Neural Cell Adhesion Molecule Isoforms in Renal Tissue: Possible Role in Incipient Renal Fibrosis.

Europe PMC ID: 26327314

Klehr et al. 2009. J Immunother. 32(5):442-51. PMID: 19609236.

FACS IP

The novel chimeric anti-NCAM (neural cell adhesion molecule) antibody ch.MK1 displays antitumor activity in SCID mice but does not activate complement-dependent cytolysis (CDC).

Europe PMC ID: 19609236

Pruszak et al. 2007. Stem Cells. 25(9):2257-68. PMID: 17588935.

Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations.

Europe PMC ID: 17588935

Blaheta et al. 2004. Neoplasia. 6(4):323-31. PMID: 15256054.

FACS

Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness.

Europe PMC ID: 15256054

Jensen et al. 2003. Clin Exp Immunol. 134(2):253-63. PMID: 14616785.

FACS

The bi-specific CD3 x NCAM antibody: a model to preactivate T cells prior to tumour cell lysis.

Europe PMC ID: 14616785

Gerardy-Schahn et al. 1994. Int J Cancer Suppl. 8:38-42. PMID: 7515028.

WB

Hot spots of antigenicity in the neural cell adhesion molecule NCAM.

Europe PMC ID: 7515028

Phimister et al. 1991. J Clin Pathol. 44(7):580-5. PMID: 1856291.

Expression of neural cell adhesion molecule (NCAM) isoforms in neuroblastoma.

Europe PMC ID: 1856291

Frost et al. 1991. Neuropathol Appl Neurobiol. 17(3):207-17. PMID: 1891065.

Expression of alternative isoforms of the neural cell adhesion molecule (NCAM) on normal brain and a variety of brain tumours.

Europe PMC ID: 1891065

Bourne et al. 1991. J Neurooncol. 10(2):111-9. PMID: 1895159.

A monoclonal antibody (ERIC-1), raised against retinoblastoma, that recognizes the neural cell adhesion molecule (NCAM) expressed on brain and tumours arising from the neuroectoderm.

Europe PMC ID: 1895159


Add a reference

References: 18 entries

Marković-Lipkovski et al. 2015. PLoS One. 10(9):e0137028. PMID: 26327314.

IHC IF

Variable Expression of Neural Cell Adhesion Molecule Isoforms in Renal Tissue: Possible Role in Incipient Renal Fibrosis.

Europe PMC ID: 26327314

Klehr et al. 2009. J Immunother. 32(5):442-51. PMID: 19609236.

FACS IP

The novel chimeric anti-NCAM (neural cell adhesion molecule) antibody ch.MK1 displays antitumor activity in SCID mice but does not activate complement-dependent cytolysis (CDC).

Europe PMC ID: 19609236

Pruszak et al. 2007. Stem Cells. 25(9):2257-68. PMID: 17588935.

Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations.

Europe PMC ID: 17588935

Blaheta et al. 2004. Neoplasia. 6(4):323-31. PMID: 15256054.

FACS

Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness.

Europe PMC ID: 15256054

Jensen et al. 2003. Clin Exp Immunol. 134(2):253-63. PMID: 14616785.

FACS

The bi-specific CD3 x NCAM antibody: a model to preactivate T cells prior to tumour cell lysis.

Europe PMC ID: 14616785

Gerardy-Schahn et al. 1994. Int J Cancer Suppl. 8:38-42. PMID: 7515028.

WB

Hot spots of antigenicity in the neural cell adhesion molecule NCAM.

Europe PMC ID: 7515028

Phimister et al. 1991. J Clin Pathol. 44(7):580-5. PMID: 1856291.

Expression of neural cell adhesion molecule (NCAM) isoforms in neuroblastoma.

Europe PMC ID: 1856291

Frost et al. 1991. Neuropathol Appl Neurobiol. 17(3):207-17. PMID: 1891065.

Expression of alternative isoforms of the neural cell adhesion molecule (NCAM) on normal brain and a variety of brain tumours.

Europe PMC ID: 1891065

Bourne et al. 1991. J Neurooncol. 10(2):111-9. PMID: 1895159.

A monoclonal antibody (ERIC-1), raised against retinoblastoma, that recognizes the neural cell adhesion molecule (NCAM) expressed on brain and tumours arising from the neuroectoderm.

Europe PMC ID: 1895159


Add a reference

References: 18 entries

Marković-Lipkovski et al. 2015. PLoS One. 10(9):e0137028. PMID: 26327314.

IHC IF

Variable Expression of Neural Cell Adhesion Molecule Isoforms in Renal Tissue: Possible Role in Incipient Renal Fibrosis.

Klehr et al. 2009. J Immunother. 32(5):442-51. PMID: 19609236.

FACS IP

The novel chimeric anti-NCAM (neural cell adhesion molecule) antibody ch.MK1 displays antitumor activity in SCID mice but does not activate complement-dependent cytolysis (CDC).

Pruszak et al. 2007. Stem Cells. 25(9):2257-68. PMID: 17588935.

Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations.

Blaheta et al. 2004. Neoplasia. 6(4):323-31. PMID: 15256054.

FACS

Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness.

Jensen et al. 2003. Clin Exp Immunol. 134(2):253-63. PMID: 14616785.

FACS

The bi-specific CD3 x NCAM antibody: a model to preactivate T cells prior to tumour cell lysis.

Gerardy-Schahn et al. 1994. Int J Cancer Suppl. 8:38-42. PMID: 7515028.

WB

Hot spots of antigenicity in the neural cell adhesion molecule NCAM.

Phimister et al. 1991. J Clin Pathol. 44(7):580-5. PMID: 1856291.

Expression of neural cell adhesion molecule (NCAM) isoforms in neuroblastoma.

Frost et al. 1991. Neuropathol Appl Neurobiol. 17(3):207-17. PMID: 1891065.

Expression of alternative isoforms of the neural cell adhesion molecule (NCAM) on normal brain and a variety of brain tumours.

Bourne et al. 1991. J Neurooncol. 10(2):111-9. PMID: 1895159.

A monoclonal antibody (ERIC-1), raised against retinoblastoma, that recognizes the neural cell adhesion molecule (NCAM) expressed on brain and tumours arising from the neuroectoderm.


Add a reference


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