Anti-NCAM [ERIC-1]
Invented by Dr JOHN KEMSHEAD from SHIRE PHARMACEUTICALS
Invented at Institute Of Child Health
- Datasheet
- References (18)
- Inventor Info
Info
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| Catalogue Number | 151092 |
| Applications | ELISA FACS IHC IF IP RIA WB |
| Antigen/Gene or Protein Targets | Neural Cell Adhesion Molecule (NCAM; CD56) |
| Synonyms | Neural Cell Adhesion Molecule; NCAM; CD56 Antigen; MSK39 |
| Reactivity | Human |
| Relevance | NCAM, also known as CD56, is a homophillic binding glycoprotein present on a variety of neural cells including neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synatptic plasticity, learning and memory and in the development of the nervous system. |
| Host | Mouse |
| Immunogen | Retinoblastoma tissue membrane fraction |
| Positive Control | Neuroblastome |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 180, 140, 120 |
| Myeloma Used | P3X63Ag8.653 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes | In the mouse brain, 3 main isoforms have been described of 180,140 and 120 kDa MW. A Western blot of 2 year old pediatric brain revealed bands of 180,140 and 120 kDa (weakly) with ERIC-1. |
| Research Area | Adhesion, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Neurobiology, Stem Cell Biology |
References: 18 entries
Marković-Lipkovski et al. 2015. PLoS One. 10(9):e0137028. PMID: 26327314.
IHC IF
Variable Expression of Neural Cell Adhesion Molecule Isoforms in Renal Tissue: Possible Role in Incipient Renal Fibrosis.
Europe PMC ID: 26327314
Klehr et al. 2009. J Immunother. 32(5):442-51. PMID: 19609236.
FACS IP
The novel chimeric anti-NCAM (neural cell adhesion molecule) antibody ch.MK1 displays antitumor activity in SCID mice but does not activate complement-dependent cytolysis (CDC).
Europe PMC ID: 19609236
Pruszak et al. 2007. Stem Cells. 25(9):2257-68. PMID: 17588935.
Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations.
Europe PMC ID: 17588935
Blaheta et al. 2004. Neoplasia. 6(4):323-31. PMID: 15256054.
FACS
Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness.
Europe PMC ID: 15256054
Jensen et al. 2003. Clin Exp Immunol. 134(2):253-63. PMID: 14616785.
FACS
The bi-specific CD3 x NCAM antibody: a model to preactivate T cells prior to tumour cell lysis.
Europe PMC ID: 14616785
Gerardy-Schahn et al. 1994. Int J Cancer Suppl. 8:38-42. PMID: 7515028.
WB
Hot spots of antigenicity in the neural cell adhesion molecule NCAM.
Europe PMC ID: 7515028
Phimister et al. 1991. J Clin Pathol. 44(7):580-5. PMID: 1856291.
Expression of neural cell adhesion molecule (NCAM) isoforms in neuroblastoma.
Europe PMC ID: 1856291
Frost et al. 1991. Neuropathol Appl Neurobiol. 17(3):207-17. PMID: 1891065.
Expression of alternative isoforms of the neural cell adhesion molecule (NCAM) on normal brain and a variety of brain tumours.
Europe PMC ID: 1891065
Bourne et al. 1991. J Neurooncol. 10(2):111-9. PMID: 1895159.
A monoclonal antibody (ERIC-1), raised against retinoblastoma, that recognizes the neural cell adhesion molecule (NCAM) expressed on brain and tumours arising from the neuroectoderm.
Europe PMC ID: 1895159
Add a reference
References: 18 entries
Marković-Lipkovski et al. 2015. PLoS One. 10(9):e0137028. PMID: 26327314.
IHC IF
Variable Expression of Neural Cell Adhesion Molecule Isoforms in Renal Tissue: Possible Role in Incipient Renal Fibrosis.
Klehr et al. 2009. J Immunother. 32(5):442-51. PMID: 19609236.
FACS IP
The novel chimeric anti-NCAM (neural cell adhesion molecule) antibody ch.MK1 displays antitumor activity in SCID mice but does not activate complement-dependent cytolysis (CDC).
Pruszak et al. 2007. Stem Cells. 25(9):2257-68. PMID: 17588935.
Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations.
Blaheta et al. 2004. Neoplasia. 6(4):323-31. PMID: 15256054.
FACS
Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness.
Jensen et al. 2003. Clin Exp Immunol. 134(2):253-63. PMID: 14616785.
FACS
The bi-specific CD3 x NCAM antibody: a model to preactivate T cells prior to tumour cell lysis.
Gerardy-Schahn et al. 1994. Int J Cancer Suppl. 8:38-42. PMID: 7515028.
WB
Hot spots of antigenicity in the neural cell adhesion molecule NCAM.
Phimister et al. 1991. J Clin Pathol. 44(7):580-5. PMID: 1856291.
Expression of neural cell adhesion molecule (NCAM) isoforms in neuroblastoma.
Frost et al. 1991. Neuropathol Appl Neurobiol. 17(3):207-17. PMID: 1891065.
Expression of alternative isoforms of the neural cell adhesion molecule (NCAM) on normal brain and a variety of brain tumours.
Bourne et al. 1991. J Neurooncol. 10(2):111-9. PMID: 1895159.
A monoclonal antibody (ERIC-1), raised against retinoblastoma, that recognizes the neural cell adhesion molecule (NCAM) expressed on brain and tumours arising from the neuroectoderm.
Add a reference
