Cat. #151092
Anti-NCAM [ERIC-1]
Cat. #: 151092
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: Neural Cell Adhesion Molecule (NCAM; CD56)
Class: Monoclonal
Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: John Kemshead
Institute: Institute of Child Health
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-NCAM [ERIC-1]
- Alternate name: Neural Cell Adhesion Molecule; NCAM; CD56 Antigen; MSK39
- Clone: ERIC-1
- Tool type ecom: Antibodies
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 180 kDa, 140 kDa, 120 kDa
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB
- Description: NCAM, also known as CD56, is a homophillic binding glycoprotein present on a variety of neural cells including neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synatptic plasticity, learning and memory and in the development of the nervous system.
- Immunogen: Retinoblastoma tissue membrane fraction
- Isotype: IgG1
- Myeloma used: P3X63Ag8.653
- Recommended controls: Neuroblastome
Target Details
- Target: Neural Cell Adhesion Molecule (NCAM; CD56)
- Molecular weight: 180 kDa, 140 kDa, 120 kDa
- Tissue cell line specificity: Neuroblastome
- Target background: NCAM, also known as CD56, is a homophillic binding glycoprotein present on a variety of neural cells including neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synatptic plasticity, learning and memory and in the development of the nervous system.
Applications
- Application: ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Markovic-Lipkovski et al. 2015. PLoS One. 10(9):e0137028. PMID: 26327314.
- Variable Expression of Neural Cell Adhesion Molecule Isoforms in Renal Tissue: Possible Role in Incipient Renal Fibrosis.
- Klehr et al. 2009. J Immunother. 32(5):442-51. PMID: 19609236.
- The novel chimeric anti-NCAM (neural cell adhesion molecule) antibody ch.MK1 displays antitumor activity in SCID mice but does not activate complement-dependent cytolysis (CDC).
- Pruszak et al. 2007. Stem Cells. 25(9):2257-68. PMID: 17588935.
- Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations.
- Blaheta et al. 2004. Neoplasia. 6(4):323-31. PMID: 15256054.
- Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness.
- Jensen et al. 2003. Clin Exp Immunol. 134(2):253-63. PMID: 14616785.
- The bi-specific CD3 x NCAM antibody: a model to preactivate T cells prior to tumour cell lysis.
- Gerardy-Schahn et al. 1994. Int J Cancer Suppl. 8:38-42. PMID: 7515028.
- Hot spots of antigenicity in the neural cell adhesion molecule NCAM.
- Phimister et al. 1991. J Clin Pathol. 44(7):580-5. PMID: 1856291.
- Expression of neural cell adhesion molecule (NCAM) isoforms in neuroblastoma.
- Frost et al. 1991. Neuropathol Appl Neurobiol. 17(3):207-17. PMID: 1891065.
- Expression of alternative isoforms of the neural cell adhesion molecule (NCAM) on normal brain and a variety of brain tumours.
- Bourne et al. 1991. J Neurooncol. 10(2):111-9. PMID: 1895159.
- A monoclonal antibody (ERIC-1), raised against retinoblastoma, that recognizes the neural cell adhesion molecule (NCAM) expressed on brain and tumours arising from the neuroectoderm.
