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Anti-EGFR [EGFR1]
RECENTLY UPDATED

Invented by Dr Peter Goodfellow at Abingworth Life Sciences

Info

Catalogue Number 151090
Applications
RECENTLY UPDATED
FACS IHC IF IP WB
Antigen/Gene or Protein Targets Epidermal Growth Factor Receptor (EGFR, Her1)
Reactivity Human
Relevance The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). Dysregulation of EGFR signaling as a consequence of overexpression, amplification and mutation of the EGFR gene occurs frequently in several types of cancers and many become dependent on EGFR signaling to maintain their malignant phenotypes.
Host Mouse
Immunogen Human epidermoid carcinoma line A431
Subclass
RECENTLY UPDATED
IgG2b kappa
Molecular Weight (kDa) 175
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area
RECENTLY UPDATED
Cancer, Cell Signaling & Signal Transduction

References: 12 entries
RECENTLY UPDATED

Finetti et al. 2015. Endocr Relat Cancer. 22(4):665-78. PMID: 26113609.

IHC

Tang et al. 2015. Oncol Rep. 34(1):350-8. PMID: 25955689.

IF WB

mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity.

Europe PMC ID: 26113609

Downregulation of CD9 promotes pancreatic cancer growth and metastasis through upregulation of epidermal growth factor on the cell surface.

Europe PMC ID: 25955689

Boersma et al. 2011. J Biol Chem. 286(48):41273-85. PMID: 21979953.

Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling.

Europe PMC ID: 21979953

Jensen et al. 2006. Proc Natl Acad Sci U S A. 103(32):11958-63. PMID: 16877544.

Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence.

Europe PMC ID: 16877544

Gullick et al. 1986. Cancer Res. 46(1):285-92. PMID: 2998607.

Expression of epidermal growth factor receptors on human cervical, ovarian, and vulval carcinomas.

Europe PMC ID: 2998607

Waterfield et al. 1982. J Cell Biochem. 20(2):149-61. PMID: 6188757.

A monoclonal antibody to the human epidermal growth factor receptor.

Europe PMC ID: 6188757


Add a reference

References: 12 entries
RECENTLY UPDATED

Finetti et al. 2015. Endocr Relat Cancer. 22(4):665-78. PMID: 26113609.

IHC

Tang et al. 2015. Oncol Rep. 34(1):350-8. PMID: 25955689.

IF WB

mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity.

Europe PMC ID: 26113609

Downregulation of CD9 promotes pancreatic cancer growth and metastasis through upregulation of epidermal growth factor on the cell surface.

Europe PMC ID: 25955689

Boersma et al. 2011. J Biol Chem. 286(48):41273-85. PMID: 21979953.

Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling.

Europe PMC ID: 21979953

Jensen et al. 2006. Proc Natl Acad Sci U S A. 103(32):11958-63. PMID: 16877544.

Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence.

Europe PMC ID: 16877544

Gullick et al. 1986. Cancer Res. 46(1):285-92. PMID: 2998607.

Expression of epidermal growth factor receptors on human cervical, ovarian, and vulval carcinomas.

Europe PMC ID: 2998607

Waterfield et al. 1982. J Cell Biochem. 20(2):149-61. PMID: 6188757.

A monoclonal antibody to the human epidermal growth factor receptor.

Europe PMC ID: 6188757


Add a reference

References: 12 entries
RECENTLY UPDATED

Finetti et al. 2015. Endocr Relat Cancer. 22(4):665-78. PMID: 26113609.

IHC

Tang et al. 2015. Oncol Rep. 34(1):350-8. PMID: 25955689.

IF WB

mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity.

Downregulation of CD9 promotes pancreatic cancer growth and metastasis through upregulation of epidermal growth factor on the cell surface.

Boersma et al. 2011. J Biol Chem. 286(48):41273-85. PMID: 21979953.

Bispecific designed ankyrin repeat proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling.

Jensen et al. 2006. Proc Natl Acad Sci U S A. 103(32):11958-63. PMID: 16877544.

Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence.

Gullick et al. 1986. Cancer Res. 46(1):285-92. PMID: 2998607.

Expression of epidermal growth factor receptors on human cervical, ovarian, and vulval carcinomas.

Waterfield et al. 1982. J Cell Biochem. 20(2):149-61. PMID: 6188757.

A monoclonal antibody to the human epidermal growth factor receptor.


Add a reference


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