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Anti-EGFR [EGFR1]

Info

Catalogue Number 151090
Applications FACS IHC IF IP WB
Antigen/Gene or Protein Targets Epidermal Growth Factor Receptor (EGFR, Her1)
Reactivity Human
Relevance The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). Dysregulation of EGFR signaling as a consequence of overexpression, amplification and mutation of the EGFR gene occurs frequently in several types of cancers and many become dependent on EGFR signaling to maintain their malignant phenotypes.
Host Mouse
Immunogen Human epidermoid carcinoma line A431
Subclass IgG2b
Molecular Weight (kDa) 175
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Cancer, Cell Signaling & Signal Transduction

References: 6 entries

Finetti et al. 2015. Endocr Relat Cancer. 22(4):665-78. PMID: 26113609.

IHC

Tang et al. 2015. Oncol Rep. 34(1):350-8. PMID: 25955689.

IF WB

Boersma et al. 2011. J Biol Chem. 286(48):41273-85. PMID: 21979953.

Jensen et al. 2006. Proc Natl Acad Sci U S A. 103(32):11958-63. PMID: 16877544.

Gullick et al. 1986. Cancer Res. 46(1):285-92. PMID: 2998607.

Waterfield et al. 1982. J Cell Biochem. 20(2):149-61. PMID: 6188757.


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