Cancer Research Technology
Log in Register
Menu

Anti-CyclinA [E23.1]

Invented by Julian Gannon at The Francis Crick Institute

Info

Catalogue Number 151088
Applications FACS IHC IF IP WB
Antigen/Gene or Protein Targets Cyclin A
Synonyms CCNA1; Cyclin A1; Testicular Tissue Protein Li 34; CT146
Reactivity Mammalian
Relevance Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. Cyclin A is a marker for actively proliferating cells and for cells in S phase. E23.1 is extremely sensitive for immunoblotting Cyclin A.
Host Mouse
Immunogen Bovine Cyclin A fusion protein.
Subclass IgG2a
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Research Area Cancer, Cell Cycle, Epigenetics & Nuclear Signalling

References: 10 entries

Hagen et al. 2013. Cell Div. 8(1):10. PMID: 23886499.

Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis.

Europe PMC ID: 23886499

Li et al. 2012. Proc Natl Acad Sci U S A. 109(31):12550-5. PMID: 22802651.

Gap 1 phase length and mouse embryonic stem cell self-renewal.

Europe PMC ID: 22802651

Hogg et al. 2011. Free Radic Biol Med. 50(9):1065-74. PMID: 21256959.

Effect of nitric oxide on neointimal hyperplasia based on sex and hormone status.

Europe PMC ID: 21256959

Geley et al. 2001. J Cell Biol. 153(1):137-48. PMID: 11285280.

Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.

Europe PMC ID: 11285280

Adamczewski et al. 1993. J Virol. 67(11):6551-7. PMID: 8411358.

Simian virus 40 large T antigen associates with cyclin A and p33cdk2.

Europe PMC ID: 8411358


Add a reference

References: 10 entries

Hagen et al. 2013. Cell Div. 8(1):10. PMID: 23886499.

Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis.

Europe PMC ID: 23886499

Li et al. 2012. Proc Natl Acad Sci U S A. 109(31):12550-5. PMID: 22802651.

Gap 1 phase length and mouse embryonic stem cell self-renewal.

Europe PMC ID: 22802651

Hogg et al. 2011. Free Radic Biol Med. 50(9):1065-74. PMID: 21256959.

Effect of nitric oxide on neointimal hyperplasia based on sex and hormone status.

Europe PMC ID: 21256959

Geley et al. 2001. J Cell Biol. 153(1):137-48. PMID: 11285280.

Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.

Europe PMC ID: 11285280

Adamczewski et al. 1993. J Virol. 67(11):6551-7. PMID: 8411358.

Simian virus 40 large T antigen associates with cyclin A and p33cdk2.

Europe PMC ID: 8411358


Add a reference

References: 10 entries

Hagen et al. 2013. Cell Div. 8(1):10. PMID: 23886499.

Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis.

Li et al. 2012. Proc Natl Acad Sci U S A. 109(31):12550-5. PMID: 22802651.

Gap 1 phase length and mouse embryonic stem cell self-renewal.

Hogg et al. 2011. Free Radic Biol Med. 50(9):1065-74. PMID: 21256959.

Effect of nitric oxide on neointimal hyperplasia based on sex and hormone status.

Geley et al. 2001. J Cell Biol. 153(1):137-48. PMID: 11285280.

Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.

Adamczewski et al. 1993. J Virol. 67(11):6551-7. PMID: 8411358.

Simian virus 40 large T antigen associates with cyclin A and p33cdk2.


Add a reference


This reagent does not have any reviews at the moment.