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Anti-PTPRC [C11]


Catalogue Number 151082
Applications IHC IP
Antigen/Gene or Protein Targets Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45)
Reactivity Human
Relevance PTPRC is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). C11 may be used for differential diagnosis of lymphoma and carcinoma and identification of haemopoietic tumours.
Host Mouse
Immunogen Human lymphocytes
Subclass IgG2a
Molecular Weight (kDa) 180-222
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Cardiovascular, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Neurobiology, Stem Cell Biology

References: 1 entry

Williams et al. 2003. Clin Exp Immunol. 131(1):68-74. PMID: 12519388.

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