Anti-Cytochrome P450 2B1, 2B2 [b/e3]
Invented by Prof Roland Wolf from University of Dundee
Invented at University of Dundee
- Datasheet
- References (3)
- Inventor Info
Info
| Catalogue Number | 151064 |
| Applications | ELISA IP WB |
| Antigen/Gene or Protein Targets | Cytochromes P450 2B1, 2B2, CYP2B1, CYP2B2 |
| Reactivity | Mouse and Rat |
| Relevance |
The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. CYP2B1 and CYP2B2 are the major phenobarbital-inducible rat hepatic cytochromes P450s. This reagent was created through a research collaboration between Cancer Research UK and Syngenta Crop Protection AG. |
| Host | Mouse |
| Immunogen | Rat liver cytochromes p450 2B1 and 2B2 |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 52 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Notes |
Clone b/e3 inhibits PROD activity in liver microsomes of PB-treated rats and inhibits ECOD activity in liver microsomes of PB-treated but not 3MC-treated rats. The CYP2B1 antibody recognises the major barbiturate-inducible P450s in mouse and rat. Syngenta Crop Protection AG is the owner of this product. |
| Research Area | Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism |
References: 3 entries
Chanyshev et al. 2020. Toxicol Mech Methods. 30(8):562-569. PMID: 32508177.
Rencurel et al. 2005. J Biol Chem. 280(6):4367-73. PMID: 15572372.
Forrester et al. 1992. Biochem J. 281 ( Pt 2):359-68. PMID: 1736885.
Add a reference
References: 3 entries
Chanyshev et al. 2020. Toxicol Mech Methods. 30(8):562-569. PMID: 32508177.
Rencurel et al. 2005. J Biol Chem. 280(6):4367-73. PMID: 15572372.
Forrester et al. 1992. Biochem J. 281 ( Pt 2):359-68. PMID: 1736885.
Add a reference
Inventor Information
Inventors
|
Prof Roland Wolf |
