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Catalogue Number
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160867 |
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Antigen/Gene or Protein Targets
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G0/G1 switch gene 2
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Synonyms
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G0/G1 swithc gene 2
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Model
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Knock-Out
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Relevance
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seful model for the generation of tissue/cell specific G0S2-deficient mice. Animals might be useful for studies, e.g.on energy metabolism or oncology.
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Production Details
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The whole G0s2 gene sequence was targeted and flanked by loxP sites. Further details are available upon request.
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Breeding Information
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Good breeder. Homozygous mice may be bred together to maintain a live colony.
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Conditional
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Yes
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Conditional Description
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Flox flanked gene ready for deletion.
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Growth/Phenotype Keywords
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These mice are conditional ready, and phenotypical identical to C57BL/6J mice.
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Strain
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C57BL/6J
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Mouse Genetic Background/Cross History
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These mice were generated using HM1-ES cells. ES cell clones were injected into C57BL/6J blastocysts to enable coat colour selection of the chimeras. Mice were subsequently backcrossed to C57BL/6J (≥ 10 generations). When kept as a homozygous colony, mice are backcrossed regularly to C57BL/6J to avoid generation of subpopulations.
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Zygosity
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Homozygous
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Research Area
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Metabolism, Cell Cycle, Apoptosis and Programmed Cell Death, Cancer
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