Anti-PAX-FOXO1 [PaxF] monoclonal antibody
Invented at National Human Genome Research Institute
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 160866 |
| Applications | ChIP IHC IF IP WB ChIP-seq |
| Antigen/Gene or Protein Targets | the junction region of the PAX3-FOXO1 and the PAX7-FOXO1 fusion proteins |
| Synonyms | PFM.2 |
| Reactivity | Human |
| Relevance | Alveolar Rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer and cases with fusion oncoproteins PAX7-FOXO1 and PAX3-FOXO1 have a poor prognosis. Determination of the fusion status is important for RMS diagnostics and therapies. This antibody is specific for the PAX3-FOXO1 and PAX7-FOXO1 and therefore is a valuable tool to study the oncogenesis of ARMS. |
| Host | Mouse |
| Immunogen | KLH conjugated with peptide PF corresponding to the PAX3-FOXO1 translocation region aa 100-117 (TIGNGLSPQNSIRHNLSL) in Freund’s adjuvant |
| Positive Control | Cell lysate from FP-RMS lines (e.g., RH-4, RH-28, RH-30, RMS-13) |
| Subclass | IgG2b kappa |
| Molecular Weight (kDa) | 105 |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Research Area | Cancer |
References: 4 entries
Azorsa et al. 2021. Mod Pathol. 34(4):748-757. PMID: 33299109.
Gryder et al. 2017. Cancer Discov. 7(8):884-899. PMID: 28446439.
Cao et al. 2010. Cancer Res. 70(16):6497-508. PMID: 20663909.
Khan et al. 1999. Proc Natl Acad Sci U S A. 96(23):13264-9. PMID: 10557309.
Add a reference
References: 4 entries
Azorsa et al. 2021. Mod Pathol. 34(4):748-757. PMID: 33299109.
Gryder et al. 2017. Cancer Discov. 7(8):884-899. PMID: 28446439.
Cao et al. 2010. Cancer Res. 70(16):6497-508. PMID: 20663909.
Khan et al. 1999. Proc Natl Acad Sci U S A. 96(23):13264-9. PMID: 10557309.
Add a reference
