Anti-troponin 1 [20] monoclonal antibody
Invented by Peter Cummins
Invented at University Of Birmingham
- Datasheet
- References (2)
- Inventor Info
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| Catalogue Number | 160857 |
| Applications | ELISA WB |
| Antigen/Gene or Protein Targets | Human Cardiac Troponin 1 |
| Synonyms | CdTn1, cTn1 |
| Reactivity | Human and Dog |
| Relevance | Cardiac and skeletal muscle contraction involves the cyclic interaction of myosin cross bridges with actin involving the concomitant hydrolysis of Mg ATP. Troponin and tropomyosin, located on the actin thin filament, are responsible for the calcium dependent regulation of the contractile process by responding to changes in the intracellular free calcium concentration. Muscle contraction is initiated by the binding of calcium to troponin C; this initiates a cascade of allosteric changes in the troponin/ tropomyosin complex, releasing the inhibitory troponin-I/actin interaction, and resulting in tropomyosin rotating radially on the thin filament from the inhibitory position. This allows actin and myosin to interact fully and, therefore, contraction to ensue. |
| Immunogen | Canine and Human CdTn1 |
| Positive Control | IgG2a |
| Notes |
Reacts with native human CdTnI but not with the recombinant protein. |
| Research Area | Cardiovascular |
References: 2 entries
Al-Hillawi et al. 1998. Eur J Biochem. 256(3):535-40. PMID: 9780229.
Cummins et al. 1987. Am Heart J. 113(6):1333-44. PMID: 3591601.
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References: 2 entries
Al-Hillawi et al. 1998. Eur J Biochem. 256(3):535-40. PMID: 9780229.
Cummins et al. 1987. Am Heart J. 113(6):1333-44. PMID: 3591601.
Add a reference
Inventor Information
Inventors
|
Peter Cummins |
