Anti-Delta Np73 [Delta Np73-3.1] monoclonal antibody
Invented at Moravian Biotechnology
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Info
| Catalogue Number | 160750 |
| Applications | IHC IP WB |
| Antigen/Gene or Protein Targets | Delta Np73 |
| Synonyms | p73 variant lacking the N-terminal transactivation domain |
| Reactivity | N/A |
| Relevance | Delta Np73 is capable of regulating TAp73 and p53 function |
| Host | Mouse |
| Immunogen | peptide MLYVGDPARHLATC |
| Positive Control | IgG1 |
| Notes |
Delta Np73 is capable of regulating TAp73 and p53 function since it is able to block their transactivation activity and their ability to induce apoptosis. Interestingly, expression of the Delta Np73 is strongly up-regulated by the TA isoforms and by p53, thus creating a feedback loop that tightly regulates the function of TAp73 and more importantly of p53. The regulation of Delta Np73 is exerted through a p53 responsive element located on the Delta N promoter. Expression of Delta Np73 not only regulates the function of p53 and TAp73 but also shuts off its own expression, once again finely regulating the whole system. _x000D_ PMID: 11753569 |
| Research Area | Cancer |
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