Anti-phospho-HSP90 [GDD8.2] monoclonal antibody
Invented at Moravian Biotechnology
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Info
| Catalogue Number | 160749 |
| Applications | WB |
| Antigen/Gene or Protein Targets | HSP90 - GDDD(pT)(pS)RMEEVD |
| Synonyms | Phosphorylated heat shock protein 90 |
| Relevance | Heat shock protein 90 (Hsp90) is a molecular chaperone that carries out processes in normal and cancer cells. Hsp90 function in vivo is coupled to its ability to hydrolyze ATP and this can be regulated by co-chaperones and post-translational modifications. |
| Host | Mouse |
| Immunogen | GDDD(pT)(pS)RMEEVD |
| Immunogen UniProt ID | P07900 |
| Positive Control | IgG |
| Notes |
Western blot reactivity shows HSP90-double phospho-TS. _x000D_ _x000D_ Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792)._x000D_ _x000D_ Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397)._x000D_ _x000D_ In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397)._x000D_ _x000D_ Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397)._x000D_ _x000D_ Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). |
| Research Area | Cancer, Cell Cycle, Epigenetics & Nuclear Signalling |
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