Anti-DJ-1 [E2-1A] monoclonal antibody
Invented at Stony Brook University
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 160671 |
| Applications | IHC WB |
| Antigen/Gene or Protein Targets | DJ-1 |
| Synonyms | PARK7 |
| Reactivity | Human |
| Relevance | DJ-1 is a broadly conserved protein among both prokaryotic and eukaryotic cells. It has been identified as playing a diverse role in a range of cellular processes. DJ-1 was originally proposed to be a pro-oncogene, and has since been shown to be expressed at varying levels in breast, non-small cell lung and prostate cancer. It has been demonstrated to paly a role in the regulation of RNA-binding proteins as well as the regulation of testicular androgen receptors and fertilization. In addition, mutations in DJ-1 have been linked to autosomal recessive early-onset familial Parkinson's disease, and have been shown to be a key component of the oxidative stress and ubiquitin-proteasome system response (see Hod, 2004 PMID: 15258905 for additional details). |
| Host | Mouse |
| Immunogen | Full length recombinant human DJ-1 |
| Subclass | IgM |
| Molecular Weight (kDa) | 24 |
| Notes | Hybridoma cell line |
| Research Area | Cancer, Reproductive Biology, Neurobiology, Apoptosis and Programmed Cell Death |
References: 2 entries
Hod et al. 2004. J Cell Biochem. 92(6):1221-33. PMID: 15258905.
Hod et al. 1999. J Cell Biochem. 72(3):435-44. PMID: 10022524.
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References: 2 entries
Hod et al. 2004. J Cell Biochem. 92(6):1221-33. PMID: 15258905.
Hod et al. 1999. J Cell Biochem. 72(3):435-44. PMID: 10022524.
Add a reference
