Anti-ORF45 [8B8] monoclonal antibody
Invented at Florida State University
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 160643 |
| Applications | IP |
| Antigen/Gene or Protein Targets | Open Reading Frame 45 clone [8B8] |
| Reactivity | Other Species |
| Relevance |
Kaposi's sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi's sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015). ORF45 (tegument) is a gene associated with the lytic viral life cycle of KSHV and has been shown to have multiple functions throughout the viral life cycle. ORF45 is a crucial component of progeny virion production in conjunction with ORF33. ORF45 binds to and stabilizes ORF33. This anti-ORF45 has been shown to purify different populations of ORF45 as well as enable the targeted depletion or enrichment of subpopulations of ORF45. This anti-ORF45 was generated using a baculovirus-synthesized ORF45 as an antigen. This specific Anti-ORF45 mouse monoclonal antibody clone [8B8] was developed for the isolation of ORF45 under native conditions via immunoaffinity purification. |
| Host | Mouse |
| Immunogen | A baculovirus-synthesized ORF45 was used as an antigen |
| Subclass | IgG |
| Research Area | Gene Expression, Virology |
