Cancer Research Technology
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BCH-N-KB Neuroblastoma cell line

Invented at University Of Birmingham

Info

Catalogue Number 160626
Host Human
Disease Keywords Neuroblastoma
Model Cancer Model
Relevance Neuroblastoma is the most common extracranial solid malignancy in children. The disease possesses a broad range of clinical phenotypes with widely varying prognoses.

Standard clinical and pathological assessments do not always differentiate reliably between tumor subtypes and, therefore, genetic markers are now playing an increasingly important role in treatment decisions.
Research Area Cancer
Growth/Phenotype Keywords Cell lines may contain both neuronal and stromal/substrate adherent (N & S) cell types - this is a recognized characteristic of many neuroblastoma cell lines
Recommended Growing Conditions Growth medium: DME/F12+15% fetal calf serum + glutamine + non-essential amino acids.
Notes Tissue Site: Adrenal Gland
Patient Sex: Male

Neuroblastoma cells have been used for the following:
- Investigation of metabolic profiles generated by in vitro H MRS
- Characterisation of genetic pathways
- Discovery of epigenetically deregulated genes during neuroblastoma tumorigenesis, using genome wide DNA methylation analysis
- Functional investigation of MEGF10 knockdown

Karyotype data available on request
STR data available on request
Cellosaurus ID TBC

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