Super pure Bovine Serum Albumin
Invented by Andrzej Gamian , Arkadiusz Bartyś , Magdalena Staniszewska , Regina Danielewicz , Katarzyna Dzierzba , Agnieszka Szydełko , Jadwiga Pietkiewicz
Invented at Polish Center for Technology Development/Polski Ośrodek Rozwoju Technologii (PORT)
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 160589 |
| Synonyms | Bovine serum albumin, BSA |
| Relevance |
Bovine serum albumin (BSA) is one of the least expensive, commercially available proteins. It is widely used as a model protein in pure research and a number of practical uses. BSA is also used in the construction of conjugated vaccines. After binding to polysaccharide antigens, it is possible to obtain effective and safe vaccines against pathogens. In a similar system, BSA is also used in neoplasm therapy. In such uses, BSA should have a high degree of purity. In particular, it should lack carbohydrate contamination. Earlier reports indicate the presence of high molecular weight derivatives in BSA preparations. Highly polymerized aggregates may form as a result of the reaction of the protein with reactive carbonyl compounds by way of glycation. The risk of the formation of such contaminating aggregates is possible due to the presence of reducing sugars in the protein environment. Additionally, the presence of saccharide conjugates and high-molecular mass derivatives in available commercial BSA preparations excludes them from use in primary research in molecular biology. For this reason, it is necessary to obtain BSA in monomeric form and lacking saccharide inclusions. |
| Research Area | Drug Discovery & Development, Other |
References: 1 entry
References: 1 entry
Inventor Information
Inventors
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Andrzej Gamian |
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Arkadiusz Bartyś |
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Magdalena Staniszewska |
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Regina Danielewicz |
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Katarzyna Dzierzba |
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Agnieszka Szydełko |
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Jadwiga Pietkiewicz |
