RYDERY Peptide
Invented by Andrzej Gamian , Edmund Ziomek , Danuta Witkowska , Anna Ewelina Jarząb
Invented at Polish Center for Technology Development/Polski Ośrodek Rozwoju Technologii (PORT)
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 160578 |
| Amino Acid Sequence | RYDERY |
| Cellular/Tissue Localisation | Umbilical blood |
| Synonyms | Shigella flexneri 3a OMP |
| Relevance | The genus Shigella belongs to Gram-negative opportunistic human pathogens and is responsible for colonic infections. Symptoms of infection include lower abdominal pain, fever and bloody diarrhoea which may cause a life threatening dehydration. Bacterial diarrhoea is in third place world wide in terms of causes of juvenile mortality below the age of five years. Infant and child mortality due to bacterial infections are generally caused by low standards of sanitation pervasive in developing nations. Nevertheless, infections by pathogenic intestinal bacteria, including Shigella, also occur in developed nations. Here, a bigger problem consists of strains resistant to antibiotics. For this reason, healthcare authorities both in developing and developed nations are pushing for prevention, including vaccination. Thus far, no one has managed to produce a vaccine against opportunistic bacterial pathogens of the gastrointestinal tract. |
| Notes |
Adapted from WO2014073998: This is a protein of the external cell wall of Shigella flexneri 3a with a molecular mass of 38 kDa which is immunoreactive with human serum. One potential application, amongst others, is its possible use as a carrier for use in conjugate vaccines. It is an epitope recognized by umbilical blood antibodies specific against enterobacteria, which may be used in the production of vaccines against Enterobacteriaceae, particularly opportunistic gastrointestinal bacterial pathogens, particularly bacteria of the genus Shigella. |
| Research Area | Bacteriology, Drug Discovery & Development, Immunology |
References: 1 entry
References: 1 entry
Inventor Information
Inventors
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Andrzej Gamian |
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Edmund Ziomek |
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Danuta Witkowska |
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Anna Ewelina Jarząb |
