- Datasheet
- References (2)
- Inventor Info
Info
![Image thumbnail for Anti-Cadherin 11 [16a] monoclonal antibody](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/23184d3b-a299-495d-8a39-e0a5efa9054a.jpg)
| Catalogue Number | 160534 |
| Applications | WB |
| Antigen/Gene or Protein Targets | Extracellular domain of cadherin-11 |
| Synonyms | CDH11, Cadherin 11, Cadherin-11 |
| Reactivity | Human |
| Relevance |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherins are known to be involved in cell migration. Changes in cadherin expression can be involved in the metastasis of cancerous cells impacting the stage, grade and prognosis of carcinomas. |
| Immunogen | Glutathione‐S‐transferase (GST) fusion protein of the extracellular domain of cadherin‐11 |
| Myeloma Used | Sp2/0 |
| Notes |
From Bussemakers et al. Int J Cancer. 2000 Feb 1;85(3):446-50. "A glutathione‐S‐transferase (GST) fusion protein of the extracellular domain of cadherin‐11 was produced in a prokaryotic system and purified fusion protein was used for immunisation of mice. Monoclonal antibody (MAb)‐producing hybridomas were obtained by fusing the spleen of immunised mice with SP20 cells. Before use, the MAb was purified on a Protein‐A column." |
| Research Area | Adhesion, Cancer, Cell Structure and Motility |
References: 2 entries
Tomita et al. 2000. Cancer Res. 60(13):3650-4. PMID: 10910081.
WB
Bussemakers et al. 2000. Int J Cancer. 85(3):446-50. PMID: 10652439.
WB
Add a reference
References: 2 entries
Tomita et al. 2000. Cancer Res. 60(13):3650-4. PMID: 10910081.
WB
Bussemakers et al. 2000. Int J Cancer. 85(3):446-50. PMID: 10652439.
WB
Add a reference
