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Small Molecules (Tool Compounds)

CS-5c Bcr-Abl and Btk small molecule kinase inhibitors

Invented by Cristian Salas
Invented at Pontificia Universidad Catolica de Chile
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1. CS-5d (9-(Cyclopropylmethyl)-N6-(3,4-difluorophenyl)-N2-(4-(4-methylpiperazin-1-yl)phenyl)-9H-purine-2,6-diamine) 2. CS-5c (9-(Cyclopropylmethyl)-N6-(3-fluorophenyl)-N2-(4-(4-methylpiperazin-1-yl)phenyl)-9H-purine-2,6-diamine)
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Catalogue Number 160518
Antigen/Gene or Protein Targets Bcr-Abl and Btk kinases
Type Inhibitor
Relevance This compound inhibits in nanomolar scale for Bcr-Abl (40 nM) and sub-micromolar scale for Btk kinases (0,58 μM), both are related to the genesis and progression of myeloid and lymphoid leukaemia, respectively
Molecular Formula C26H29FN8
lUPAC 9-(Cyclopropylmethyl)-N6-(3-fluorophenyl)-N2-(4-(4-methylpiperazin-1-yl)phenyl)-9H-purine-2,6-diamine
Molecular Weight (g/mol) 472.5605
Solubility DMSO
Research Area Cancer
Storage Away from UV light

References

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References: 1 entry

Bertrand et al. 2020. Bioorg Chem. 94:103361. PMID: 31699386.

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References: 1 entry

Bertrand et al. 2020. Bioorg Chem. 94:103361. PMID: 31699386.

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