Anti-CD54 [YN1/1.7.4] monoclonal antibody
Invented at BC Cancer
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 160510 |
| Applications | FACS IP WB |
| Antigen/Gene or Protein Targets | CD54 |
| Synonyms | ICAM-1 |
| Reactivity | Mouse |
| Relevance |
CD-54, also known as ICAM-1, is a cell surface glycoprotein expressed on epithelial, lymphocytes, macrophages, dendritic cells, and other immune cells. It plays a role in cellular signalling to stabilize cell-cell interactions and also binds to integrins of type CD11a/CD18 and CD11b/CD18. It has also been shown to be a target for rhinoviruses. This antibody recognizes the murine lymphocyte antigen MALA-2. This antibody inhibits the mixed lymphocyte response and inhibits Con A blasts to MALA-2. This antibody was purified from ascite fluid using ammonium sulfate (50% saturation) precipitation followed by DEAE affi-gel blue chromatography. |
| Host | Rat |
| Immunogen | NS-1 cells |
| Subclass | IgG2b kappa |
| Molecular Weight (kDa) | 95 |
| Myeloma Used | Y3 |
| Notes | This antibody can be used for blocking and functional studies in addition to applications listed. |
| Research Area | Immunology, Cancer |
References: 2 entries
Horley et al. 1989. EMBO J. 8(10):2889-96. PMID: 2573511.
Takei et al. 1985. J Immunol. 134(3):1403-7. PMID: 2981916.
Add a reference
References: 2 entries
Horley et al. 1989. EMBO J. 8(10):2889-96. PMID: 2573511.
Takei et al. 1985. J Immunol. 134(3):1403-7. PMID: 2981916.
Add a reference
