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A549p0#1a Cell Line
RECENTLY UPDATED

Invented at University of South Alabama

Info

Catalogue Number 160508
Parental Line A549
Host Human
Tissue Lung
Disease Keywords Mitochondrial Disease
Conditional No
Research Area DNA Damage and Repair, Drug Discovery & Development, Metabolism
Notes Derived from A549 human lung adenocarcinoma cell line, these cells lack both mitochondrial DNA (mtDNA) and a functional mitochondrial electron transport chain and are auxotrophic for uridine and pyruvate. These cells can be repopulated with exogenous mtDNA (e.g., mtDNA from patients with mitochondrial disease) allowing for mitochondrial mutational analysis.

The original parental lines are available upon request.

References

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References: 1 entry

Khozhukhar et al. 2018. Curr Protoc Cell Biol. 78(1):20.11.1-20.11.14. PMID: 30040188.


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References: 1 entry

Khozhukhar et al. 2018. Curr Protoc Cell Biol. 78(1):20.11.1-20.11.14. PMID: 30040188.


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Inventor Information

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