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Catalogue Number
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160399 |
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Applications
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Fn
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Antigen/Gene or Protein Targets
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Elafin; SKALP
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Synonyms
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Elastase-specific inhibitor (ESI), Peptidase inhibitor 3 (PI-3), Protease inhibitor WAP3,Skin-derived antileukoproteinase (SKALP), WAP four-disulfide core domain protein 14
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Reactivity
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N/A
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Relevance
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Some anti-elastase activity is found in cultured keratinocytes and in epidermis from psoriasis patients, but not in normal human epidermis. This inhibitory effect has been shown to be mediated by SKALP, Skin-derived antileukoproteinase also known as Elafin.
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Host
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Rabbit
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Immunogen
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human SKALP/Elafin derived from psoriatic scales
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Molecular Weight (kDa)
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18kDa
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Notes
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This polyclonal antibody was raised against human SKALP (Elafin) protein extracted from human psoriatic scales and shown to inhibit human leukocyte elastase. It was sequenced and shown to have 40% homology with the active site of antileukoproteinase (ALP) a known serine proteinase inhibitor present in mucous secretions.
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Research Area
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Dermatology
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Immunogen UniProt ID
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P19957
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