Tin Tungstate Nanoparticles β-SnWO4 small molecule (tool compound)
Invented by Claus Feldmann
Invented at Karlsruhe Institute of Technology
- References (3)
- Inventor Info
|Antigen/Gene or Protein Targets||near-surface tumours|
|Relevance||Tin Tungstate nanoparticles act as photosensitizers for photodynamic tumor therapy of near-surface tumors via reiterated 5 min blue-light LED illumination.|
|In vivo applications||Used to treat tumours in BALB/C mice orthotopically inoculated with the 4T1 breast cancer cell line. Reduced lymph node metastases.|
|In vitro applications||Killed 4T1 cells in vitro.|
"The nanoparticulate inorganic photosensitizer β-SnWO4 is suggested for photodynamic therapy (PDT) of near-surface tumors via reiterated 5 min blue-light LED illumination. β-SnWO4 nanoparticles are obtained via water-based synthesis and comprise excellent colloidal stability under physiological conditions and high biocompatibility at low material complexity. Antitumor and antimetastatic effects were investigated with a spontaneously metastasizing (4T1 cells) orthotopic breast cancer BALB/c mouse model. Besides protamine-functionalized β-SnWO4 (23 mg/kg of body weight, in PBS buffer), chemotherapeutic doxorubicin was used as positive control (2.5 mg/kg of body weight, in PBS buffer) and physiological saline (DPBS) as a negative control. After 21 days, treatment with β-SnWO4 resulted in a clearly inhibited growth of the primary tumor (all tumor volumes below 3 cm3) as compared to the doxorubicin and DPBS control groups (volumes up to 6 cm3). Histological evaluations of lymph nodes and lungs as well as the volume of ipsilateral lymph nodes show a remarkable antimetastatic effect being similar to chemotherapeutic
doxorubicin butaccording to blood countsat significantly reduced side effects. On the basis of low material complexity,
high cytotoxicity under blue-light LED illumination at low dark and long-term toxicity, β-SnWO4 can be an interesting
addition to PDT and the treatment of near-surface tumors, including skin cancer, esophageal/gastric/colon tumors as well
as certain types of breast cancer."
From Seidl et al 2016, ACS Nano, 10, 3149−3157.
There are 3 reference entries for this reagent.View All References