Anti-cancer inhibitor of protein phosphotase 2A [2G10-3B5] monoclonal antibody
Invented at University Of Florida
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 158415 |
| Applications | IHC IF WB |
| Antigen/Gene or Protein Targets | Cancerous Inhibitor of Protein Phosphatase 2A |
| Synonyms | CIP2A |
| Reactivity | Human, Rat and Mouse |
| Relevance | CIP2A is an oncoprotein that inhibits PP2A tumor suppressor activity in human malignancies by preventing degredation of c-Myc and regulates the phosphorylation of many oncoproteins. CIP2A is required for malignant cellular growth and tumor formation and is overexpressed in several human cancers: head and neck squamous cell carcimona, colon cancer, gastric cancer, breast cancer, prostate cancer, and lung caner. |
| Host | Mouse |
| Immunogen |
MAb were generated using the C-terminal third of the recombinant human protein as antigen |
| Subclass | IgG2b kappa |
| Research Area | Cancer, Cell Signaling & Signal Transduction |
