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Catalogue Number
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158411 |
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Applications
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ELISA
IHC
WB
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Antigen/Gene or Protein Targets
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interferon-inducible double strane RNA-dependent protein kinease/Protein activator of the interferon-induced protein kinase (Rax/PACT)
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Synonyms
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RAX/PACT; PRKRA
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Reactivity
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Human, Rat and Mouse
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Relevance
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Rax (mouse protein) and PACT (human ortholog) are the only known activators of PKR (double-stranded RNA dependent kinase). Rax and PACT share 98% amino acid sequence homology and contain three conserved dsRNA binding motifs. Phosphorylation of Serine 18 of RAX is required for PKR activation, which is known to be involved in the host anti-viral response, and can act as a signaling mediator by cytokines, growth factors and even tumor supressors.
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Host
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Mouse
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Immunogen
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Two synthetic peptides corresponded to amino acids 13-25, containing phosphorylated and non-phosphorylated Ser 18 of PACT of mouse origin
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Subclass
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IgG2b kappa
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Research Area
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Cell Signaling & Signal Transduction
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