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Catalogue Number
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158399 |
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Antigen/Gene or Protein Targets
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PIK3C3
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Model
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Knock-In
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Production Details
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Knock-in mice in which the endogenous PIK3C3/vps34 PI3K gene is mutated so that it now encodes a vps34 protein with the D761A mutation in the ATP binding site, converting it to a kinase-dead vps34 protein which is expressed at the same level as wild-type vps34. These mice have been backcrossed onto the B6 background.
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Mouse Genetic Background/Cross History
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Backcrossed onto C57B6/J for more than 10 generations.
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Research Area
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Cancer
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Notes
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Homozygous mice show prenatal partial lethality at early embryonic stages between embryonic day (E) 6.5 and 8.5 (see PMID 29180704 for details). Heterozygous mice are healthy and display a robustly enhanced insulin sensitivity and glucose tolerance as well as a partial protection against high-fat-diet-induced liver steatosis. (see PMID 29180704 for details).
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