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Catalogue Number
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158398 |
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Antigen/Gene or Protein Targets
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PIK3C2B
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Model
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Knock-In
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Production Details
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Knock-in mice in which the endogenous PIK3C2B/PI3K-C2beta PI3K gene is mutated so that it now encodes a PI3K-C2beta protein with the D1212A mutation in the ATP binding site, converting it to a kinase-dead PI3K-C2beta protein which is expressed at the same level as wild-type PI3K-C2beta. These mice have been backcrossed onto the B6 background.
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Mouse Genetic Background/Cross History
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Backcrossed onto C57B6/J for more than 10 generations.
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Research Area
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Cancer
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Notes
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Homozygous mice are phenotypically normaland born at a normal Mendelian ratio, with no impact on organismal growth. Mice display enhanced insulin sensitivity and glucose tolerance, as well as protection against high-fat-diet-induced liver steatosis. (see PMID 26655903 for details). Heterozygous mice are phenotypically normal.
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