Pik3ca-H1047R conditional – Flp inducible
RECENTLY UPDATED
RECENTLY UPDATED
Invented by Bart Vanhaesebroeck
Invented at Ludwig Institute for Cancer Research
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 158395 |
| Antigen/Gene or Protein Targets | PIK3CA |
| Production Details | Genomic DNA covering the last 6 exons of the coding region of Pik3ca was isolated and a point mutation, resulting in conversion of CAT (H) to CGT (R) in the C terminal p110αkinase domain, was introduced by site-directed mutagenesis. In addition, a neo selection cassette flanked by frt sites was inserted into exons 19 and 20 in the targeting vector using standard restriction enzyme- and PCR-based cloning techniques. |
| Conditional | Yes |
| Mouse Genetic Background/Cross History | Backcrossed onto C57B6/J for more than 10 generations. |
| Research Area | Cancer |
| Notes | Homozygous and heterozygous mice are phenotypically normal. |
References: 1 entry
References: 1 entry
Inventor Information
Inventors
|
Bart Vanhaesebroeck |
