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p110beta PI3K-D931A (B6)
RECENTLY UPDATED

Invented by Bart Vanhaesebroeck
Invented at Ludwig Institute for Cancer Research

Info

Catalogue Number 158389
Antigen/Gene or Protein Targets PIK3CB
Production Details Knock-in mice in which the endogenous PIK3CB/p110beta PI3K gene is mutated so that it now encodes a p110beta protein with the D931A mutation in the ATP binding site, converting it to a kinase-dead p110beta protein which is expressed at the same level as wild-type p110beta. These mice have been backcrossed onto the B6 background.
Mouse Genetic Background/Cross History Backcrossed onto C57B6/J for more than 10 generations.
Research Area Cancer
Notes Mice show prenatal partial lethality at at different embryonic stages (see PMID 26132308 for details). Homozygous male mice that are born are infertile with smaller than normal testicles. They cannot produce offspring.

References

There are 2 reference entries for this reagent.

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References: 2 entries

Guillermet-Guibert et al. 2015. PLoS Genet. 11(7):e1005304. PMID: 26132308.

Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.


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References: 2 entries

Guillermet-Guibert et al. 2015. PLoS Genet. 11(7):e1005304. PMID: 26132308.

Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.


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Inventor Information