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p110beta PI3K-D931A (129)

Invented by Bart Vanhaesebroeck
Invented at Ludwig Institute for Cancer Research

Info

Catalogue Number 158388
Antigen/Gene or Protein Targets PIK3CB
Model Knock-In
Production Details Knock-in mice in which the endogenous PIK3CB/p110beta PI3K gene is mutated so that it now encodes a p110beta protein with the D931A mutation in the ATP binding site, converting it to a kinase-dead p110beta protein which is expressed at the same level as wild-type p110beta. These mice have been backcrossed onto the sv129 background.
Mouse Genetic Background/Cross History Backcrossed onto sv129 for more than 10 generations.
Research Area Cancer
Notes Mice show prenatal partial lethality at at different embryonic stages (see PMID 26132308 for details). Homozygous male mice that are born are infertile with smaller than normal testicles. They cannot produce offspring.

References

There are 2 reference entries for this reagent.

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References: 2 entries

Guillermet-Guibert et al. 2015. PLoS Genet. 11(7):e1005304. PMID: 26132308.

Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.


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References: 2 entries

Guillermet-Guibert et al. 2015. PLoS Genet. 11(7):e1005304. PMID: 26132308.

Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.


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Inventor Information