Cancer Research Technology
Log in Register
Menu

Lysine Specific Demethylase 1 (LSD1) knockout mouse

Invented by Shaun Cowley
Invented at University Of Leicester

Info

Catalogue Number 158387
Antigen/Gene or Protein Targets Lysine-Specific Demethylase 1
Synonyms LSD1, KDM1A, AOF2, KDM1, KIAA0601, LSD1
Disease Keywords Cleft palate, psychomotor retardation, and distinctive facial features (CPRF)
Model Knock-Out
Relevance Lysine-specific demethylase 1 (LSD1) acts as a coactivator or a corepressor of transcription, depending on the context, of histone H3 through demethylation of both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me). It demethylates mono- and dimethylated histone H3 as part of a larger complex. It essential for embryonic development in the mouse beyond embryonic day 6.5.
Production Details Embryos at the desired developmental stage were produced from timed Lsd1+/β-geo × Lsd1+/β-geo matings
Conditional No
Research Area Developmental Biology
Growth/Phenotype Keywords gene-trap
Notes Using this mouse model it was found that LSD1 regulates the expression and appropriate timing of key developmental regulators, as part of the LSD1/CoREST/HDAC complex, during early embryonic development.

References

There are 1 reference entries for this reagent.

View All References

References: 1 entry

Foster et al. 2010. Mol Cell Biol. 30(20):4851-63. PMID: 20713442.


Add a reference

References: 1 entry

Foster et al. 2010. Mol Cell Biol. 30(20):4851-63. PMID: 20713442.


Add a reference

Inventor Information