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Anti-CLEC16A [8C1] monoclonal antibody
RECENTLY UPDATED

Invented at The University of British Columbia

Info

Catalogue Number 158318
Applications ELISA FACS IHC IF WB DB
Antigen/Gene or Protein Targets C-Type Lectin Domain Containing 16A
Synonyms CLEC16A, KIAA0350
Reactivity Mouse
Relevance antibody against CLEC16A (specifically binds to C-terminal human peptide CLEC16A1,002-1,024: RALSGISQLPTLPAADTETPAEG)

CLEC16A is a cytosolic protein which is differentially expressed in human immune cells and is known to be highly expressed on B-lymphocytes, natural killer (NK) and dendritic cells. CLEC16A gene has been linked to several autoimmune diseases, including Addison's disease, diabetes melllitus, Crohn's disease, primary biliary cirrhosis, juvenile idiopathic arthritis, rheumatoid arthritis and multiple sclerosis. . CLEC16A has been shown to regulate various immune pathways including directly regulating leukocyte antigen class II pathway in antigen presenting cells, autophagy, mitophagy, and NK cell cytotoxicity.
Host Rat
Immunogen 23-mer C-terminal mouse peptide (CLEC16A1,002-1,024: RALSGISQLPTLPAADTETPAEG) linked to KLH
Positive Control IgG2a
Research Area Immunology, Neurobiology

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