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Info
| Catalogue Number | 158055 |
| Applications | ELISA WB |
| Antigen/Gene or Protein Targets | Interleukin 31 |
| Reactivity | Horse |
| Relevance |
IL-31 is an inflammatory cytokine that modulates cell-mediated immunity against pathogens. It is produced by activated CD4+ T lymphocytes, in particular activated Th2 helper cells, mast cells, macrophages, and dendritic cells. It's major sites of action are the skin, lung, intestine and the nervous system. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. It was reported when IL-31 is overexpressed in transgenic mice, it results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development. IL-31 and its receptors are also involved in regulating hematopoietic progenitor cell homeostasis. The antibody will elucidate the role of IL-31 in horse and shed further light on its clinical significance. |
| Host | Rabbit |
| Immunogen | Ovalbumin-conjugated synthetic peptide |
| Formulation | Unpurified anti-serum from rabbit preserved in 0.02% Thiomersal |
| Molecular Weight (kDa) | 17.7 |
| Notes |
Applications and Recommended Usage Conditions: - ELISA recommended to be used at 1/500 dilution. Recombinant IL-31 protein as positive control. - WB recommended to be used at 1/500 dilution. Recombinant IL-31 protein as positive control. Unpurified anti-serum from rabbit preserved in 0.02% Thiomersal |
| Positive Control | ELISA: Peptide immunogens & recombinant IL-31 WB: Recombinant IL-31 |
| Research Area | Cell Type or Organelle Marker, Immunology |
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Inventor Information
Inventors
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Abdo Alnabulsi |
