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Info
| Catalogue Number | 158051 |
| Applications | ELISA |
| Antigen/Gene or Protein Targets | Insulin-like growth factor 1 (IGF) |
| Reactivity | Avian |
| Relevance |
Insulin-like growth factor 1 (IGF-1) is produced by the liver and skeletal muscle as well as many other tissues in response to growth hormone (GH) stimulation. IGF-1 mediates many of the actions of GH, stimulating the growth of bones and other tissues and promoting the production of lean muscle mass. IGF-1 is a useful indicator of average GH levels. The IGF-1 test is therefore often used to help evaluate for GH deficiency or GH excess. IGF-1 deficiencies are seen early in life and are usually the result of GH deficiency. They can inhibit bone growth and overall development and can result in a child with a shorter than normal stature. In adults, decreased production can lead to low bone density, less muscle mass, and altered lipid levels. Insulin-like growth factor 1 (IGF-1) is an evolutionary conserved peptide, which has been shown to be essential in the regulation of body size, the pattern of reproductive investment and life span across a broad taxonomic range of model species in laboratory and domesticated conditions. However, studies addressing corresponding evolutionary hypotheses on a broader scale and in free-living vertebrates are very rare. This is a very useful research tool to monitor muscle development and metabolism in birds. |
| Host | Rabbit |
| Immunogen | Ovalbumin-conjugated synthetic peptide. Peptide immunogen is conserved in all bird species |
| Formulation | Unpurified anti-serum from rabbit preserved in 0.02% Thiomersal |
| Molecular Weight (kDa) | 17 |
| Notes |
Applications and Recommended Usage Conditions: - ELISA recommended to be used at 1:500 dilution. Peptide immunogen as positive control Unpurified anti-serum from rabbit preserved in 0.02% Thiomersal. |
| Positive Control | ELISA: peptide immunogen |
| Research Area | Cell Type or Organelle Marker, Immunology |
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Inventor Information
Inventors
|
Abdo Alnabulsi |
