Anti-IgM [A70 P1B5*D8] monoclonal antibody
Invented by Abdo Alnabulsi
Invented at Vertebrate Antibodies Limited
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Info
| Catalogue Number | 158032 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Immunoglobulin Heavy Constant Mu (IgM) |
| Reactivity | Nile Tilapia |
| Relevance |
IGHM (Immunoglobulin heavy constant Mu) is a protein coding gene. The IGHM gene encodes the C region of the mu heavy chain, which defines the Immunoglobulin (Ig)M isotype. Immunoglobulin is membrane-bound or is secreted by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulin serves as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulin-secreting plasma cells. Secreted immunoglobulin mediates the effector phase of humoral immunity, which results in the elimination of bound antigens. Detection of specific antibodies in the serum of animals is an indicator of previous exposure to pathogens which is very valuable for broodstocks health testing. The anti-IgM antibody provides a useful tool to monitor vaccine performance in fish and will assist in the development of future vaccines. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide |
| Positive Control | ELISA: Peptide immunogen WB: Fish serum IHC: Formalin-fixed, paraffin-embedded spleen tissues |
| Subclass | IgG1 kappa |
| Molecular Weight (kDa) | 68 |
| Strain | Balb/c |
| Notes |
Applications and Recommended Usage Conditions: - ELISA recommended to be used Neat - WB recommended to be used at 1/5 - IHC recommended to be used at 1/5, Antigen retrieval: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0. Unpurified; supplied as hybridoma supernatant Fusion Partner is Ag 8563 |
| Research Area | Cell Type or Organelle Marker, Immunology |
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Inventor Information
Inventors
|
Abdo Alnabulsi |
