Anti-CRP/SAP-1a [A13 P1B11*G7] monoclonal antibody
Invented by Abdo Alnabulsi
Invented at Vertebrate Antibodies Limited
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Info
| Catalogue Number | 158030 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Pentraxin precursor |
| Reactivity | Salmonids |
| Relevance |
The classical pentraxins, C-reactive protein (CRP) and serum amyloid P component (SAP) are serum opsonins, which bind to damaged membranes and nuclear autoantigens. Pentraxins are important in the process of complement activation and clearance of apoptotic bodies through Fcγ receptors. Pentraxins are well conserved in arthropods, fish, amphibians, and mammals. In salmon, CRP/SAP-1a is reported as one of the major acute phase proteins (APPs) and were significantly up-regulated by recombinant cytokines (rIL-1β and rIFN-γ) in primary head kidney cells. This is the only commercial antibody available. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide. Peptide immunogen is conserved in salmonids fish species. |
| Positive Control | ELISA- Peptide immunogen WB- fish serum IHC- formalin-fixed, paraffin-embedded multi-tissue microarray |
| Subclass | IgG1 kappa |
| Molecular Weight (kDa) | 26 |
| Strain | Balb/c |
| Notes |
Applications and Recommended Usage Conditions: - ELISA recommended to be used neat - WB recommended to be used at 1/5 Unpurified; supplied as hybridoma supernatant Fusion Partner is Ag 8563 |
| Research Area | Cell Type or Organelle Marker, Immunology |
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Inventor Information
Inventors
|
Abdo Alnabulsi |
